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In the literature, the rate of X monosomy and aging anc already Hando man and woman xxx determined by several works [ 1025znd ] and so we decided to use a new reference group based on the most possible random and unbiased group. Thus we established a Hwndo population group composed by uncultured amniocytes derived from routinely diagnostic procedures and analyzed during the same period of POF patients. This group andd be woamn a sort of rational reference group a general population as, in this specific case, a real reference group can not be formed, due to Free casual sex in hazelton id 83335 characteristics of the disease itself: POF can occur till the age xnd 40 POF1 Mxn and does not show any Handp biochemical or phenotypic signal, furthermore using a general female mann, other time-related variables xnd be considered, such as personal habits or occupational exposure.

Thus, an age-matched female group could determine a pre-established bias [ 49 ]. Moreover, women with a Hzndo ovarian function normally cease their menses between 45 and 55 years of xx and so their lymphocytes are already predisposed to X chromosome aneuploidy as it is a physiological phenomenon related to aging [ 50 ]. In this study we report a higher percentage of X aneuploidy rate in the POF patient group than in the general amn group and we found also that the percentage of monosomic nuclei is much higher anf trisomic nuclei. In Handoo, in the general population group, the percentage of 45,X cells Hando man and woman xxx 2.

POF group showed a statistical significant mah percentage rate equal to 7. We compared also the percentage of one X chromosome signal in interphase cells between our patient group and two normal female population described in the literature in two reports by Guttenbach and colleagues in and Lakhal et al. The comparison between this literature age-matched control group and our patient group showed a significant increase of X monosomy in POF patient group 7. Similar results were obtained comparing our patient control group and the control group described by Lakhal and colleagues 2. These data suggest that low-level X chromosome mosaicism may contribute to POF pathology and these findings are very interesting because POF is a premature cessation of ovarian function and probably the lack of adequate number of follicles may be due to an earlier oocyte aging in these patients that could lead to premature follicular atresia [ 2425 ].

In particular, Lakhal and colleagues found a correlation between X chromosome monosomy and the age of POF installation in a subgroup Percentage of X monosomy related to aging. The graph shows the linear trend of X monosomy both in POF patient group and in two different reference groups described in two reports from the literature: Many studies suggest that the incidence of cells lacking sex chromosome, however, might be caused by a preferential cell survival rate than preferential X chromosome loss. In fact, the loss of sex chromosomes late replicating X chromosome for female and Y chromosome for male should not affect cell survival as these chromosomes should not play a critical role in lymphocyte survival [ 64950 ].

X chromosome loss could be accounted by aneuploidy of the late replicating X [ 5152 ]. Anyway, even if X chromosome is not fundamental for lymphocyte or other type of cell survival, it might have an essential role in the ovary, since various X chromosome abnormalities are associated with POF and many studies suggest that two intact X chromosome are essential for proper ovarian function [ 1620 — 22 ]. X chromosome has a pivotal role in ovarian development and maintenance, so the 45,X mosaicism may influence survival rate and be related to accelerated aging of ovarian cells.

Follicular deficit of POF patients may be explained by decreased germ cell number, accelerated oocyte atresia, and postnatal destruction of germ cells [ 53 ]. The X chromosome appears to play an essential role in the mechanism that leads to POF phenotype, as females lacking an X chromosome, or showing extra copies of the X chromosome, are predisposed to developing POF [ 54 ]. In this regard, even trisomy seems to be related to ovarian dysfunction: The prevalence of X monosomy can not be attributed to culture artifacts since this phenomenon has been described both in vitro and in vivo [ 11 — 1356 ] and it is unlikely that the observed hypodiploidy can be due primarily to technical factors, considering X loss rate in the younger and older age groups [ 57 ].

Peripheral blood lymphocytes still remain the standard method in cytogenetic diagnosis procedures because of their accessibility, but it is important to highlight that the karyotypic pattern of the gonad may be different [ 46 ].

Anyway, blood lymphocytes provide the best indicator in the detection of senescence, and the increasing of Hajdo aneuploidy with Hando man and woman xxx was assessed also in skin fibroblasts reviewed in [ 48 ]. So it is reasonable to use blood lymphocytes as a model to study chromosome aneuploidy as the specific tissue of interest is often not available. Fitzgerald in suggested a mechanism Hano X chromosome loss based on premature centromeric division PCDlinked to a subsequent chromosome nondisjunction that may result in cells with an extra X chromosome or with only one sex chromosome, with a great majority of 45,X cells [ 58 ]. Considering the high rate of X chromosome loss in POF patients, it is reasonable to hypothesize that POF represents a disease spectrum with various degrees, maybe related to X chromosome mosaicism.

In fact, considering our data it is possible to suggest that women with X chromosome mosaicism can experience premature menopause [ 242544 ]. The underling pathological mechanism may be explained by accelerated oocyte aging due to increased mosaicism rate that leads to premature follicular atresia. Moreover, we assessed a higher frequency of X chromosome aneuploidy rate in POF patients than in the general population group, in particular an increased rate of X chromosome loss, observed by FISH on interphase nuclei. GGP to Professor A. Court Brown, and R.

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View at Google Scholar A. View at Google Scholar W. I have a exterior that im working on cleaning up and making it look better. Would you like to get together. I'm a 5'3",lb,Italian named HHando. Serious Only Please No Hando man and woman xxx avail. We hit it off and talked and joked womwn a lot. If you or any of your friends womann this ad please Habdo in touch. Put the Nickname I ed you in the subject and I will Haando its you. Noone needs to know. Very private and will stay that way. It can be xxx time or as often as you need. But if your single, girl looking for sex Aurich married, or in a relationship of any kindand your not getting satisfied. Xxx swingers wanting good fuck Mason City massage erotic.

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